It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine sketchy Chloroquine indications Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. I've been on Plaquenil now for three months and its starting to help with the pain although I have diarrhoea every day but it's manageable. But I'm really struggling with fatigue now - worse than its ever been. Don't know whether its the RA itself or my body reacting to Plaquenil but I can't seem to do anything without being really really tired. Plaquenil is most known for its original purpose treating and preventing malaria. Malaria is a disease caused by parasites that can enter the body through a mosquito bite. The essential ingredient, known as quinine, is derived from the bark of the cinchona plant. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil lethargy Hydroxychloroquine Side Effects, Dosage, Uses, and More, Is extreme fatigue a side effect of Plaquenil - NRAS Plaquenil avoidPlaquenil saved my lifeSide effect of plaquenil on eyesAllergic reaction to hydroxychloroquine burn how long Plaquenil is a mild DMARD disease-modifying anti-rheumatic drug that is very commonly prescribed as a "starter drug" for a wide range of autoimmune conditions. It has a very good overall safety profile and is well-tolerated by most people. Experiences taking Plaquenil for Fatigue and Muscle Pain? - Inspire. Plaquenil Hydroxychloroquine for Lupus - LupusCorner. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. Feb 19, 2020 Call your doctor at once if you have headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; very slow heart rate, weak pulse; muscle weakness, numbness or tingling; low blood sugar --headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.