Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Chloroquine dna transfection Hydroxychloroquine liver function tests Delayed side effects plaquenil Can you break plaquenil in half For severe or widespread morphea, your doctor may prescribe an immunosuppressive medication, such as oral methotrexate Trexall, corticosteroid pills or both. Or your doctor may suggest hydroxychloroquine Plaquenil. Each of these drugs has potentially serious side effects. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs. The disease can be either localized to the skin or involve other organs in addition to the skin. Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Lupus and Scleroderma - Scleroderma News, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil reviews for sjogren& 39 Oct 09, 2015 Hi, I have Raynaud's syndrome since 2010, and in 2014 I had a blood test with the result of positive ANA speckled and ACA, ACA-B. I still don't have thickening skin of the hands/fingers, but my doctors told me I have Limited Systemic Scleroderma, since anti centromere antibody ACA is a very specific scleroderma auto-antibody. Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma.. Scleroderma - Wikipedia. Scleroderma Definition, Types, Symptoms, Causes, and.. Others target specific aspects of the disease, such as the mechanisms involved in skin fibrosis. An example would be imatinib mesylate Gleevec. A third category involves medications that are used to “regulate” the immune system, such as hydroxychloroquine Plaquenil. Potential Side Effects of Scleroderma Medications Hydroxychloroquine Plaquenil is the most common anti-malarial treatment for scleroderma. It is occasionally used in combination with quinacrine, when ineffective on its own. However, quinacrine Atabrine is not available in the U. S. or Canada. Hi Maddy, My rheumatologist does consider Plaquenil to be a disease modifying drug. They truly don't know exactly how it works. It does reduce the pain and fatigue and has the ability to "stop the disease in its track and keep it from progressing" Those are my rheumatologist's exact words.