It typically happens in the evening or nighttime hours when you're sitting or lying down. Restless legs syndrome, also known as Willis-Ekbom disease, can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities. Aralen rheumatoid arthritis Hydroxychloroquine for hair loss Can plaquenil cause diarrhea Eye exam before plaquenil I have mild Lupus with no organ involvement. ANA+. For well over a year I have been experiencing ongoing, unrelenting muscle spasms and stiff, sore legs from the spasms which seem to happen most often in my lower body. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. I started on the Plaquenil a little over a week ago. Not much in the way of side effects. Some minor stomach stuff but that could be normal and not related to the Plaquenil. I started at 200mg and increased to 400mg after a week. Andie213, my fatigue has been frustrating for me as well. Medications also help many people with symptoms as abnormal, unpleasant sensations in their legs or feet. They do, however, consistently describe the desire to move their legs. Sometimes, symptoms disappear for periods of time, then come back. Simple self-care steps and lifestyle changes may help relieve symptoms. The sensations, which generally occur within the limb rather than on the skin, are described as: usually don't describe the condition as a muscle cramp or numbness. Does plaquenil caus stiff legs Polymyalgia Rheumatica Guide Causes, Symptoms and., Plaquenil for fatigue and pain DailyStrength Plaquenil weight gain reviewsChloroquine lc3bChloroquine cyanosis Muscle Stiffness in Legs after Sitting and In Morning Home Remedies Causes and Remedies for Stiffness in Legs You may have experienced this at one time or another, the painful stiffness in legs that can debilitate you or leave you immobile due to pain. Muscle Stiffness in Legs after Sitting and In Morning.. Experiences taking Plaquenil for Fatigue and Muscle Pain? - Inspire. Muscle Stiffness Causes, Diagnosis, Treatment & More. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. Jan 22, 2020 In a minority of cases, polymyalgia rheumatica is associated with giant cell arteritis temporal arteritis. This is a condition in which blood vessels are inflamed, especially in the neck and head. Untreated giant cell arteritis can cause blindness or stroke. Symptoms. Symptoms of polymyalgia rheumatica can include Sudden pain and stiffness.