Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Generic plaquenil prices Chloroquine pretreatment degradation Hydroxychloroquine mode of action Hydroxychloroquine and peripheral neuropathy The pill is a VERY common cause of dark spots in women. About 30% of women using oral estrogen report having melasma like facial pigmentation. Treatment of hormone-induced melasma works best after breastfeeding has stopped, a woman is no longer pregnant, or her contraceptives have changed. Mar 16, 2011 I have been on it for 8 months straight this time joint pain has improved. I now have hyperpigmentation a darkening or tanned effect on my face and forearms that showed up several months ago and it looks similar to Melasma, I have researched and found this is a side effect of plaquenil. Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil cause melasma Melasma skin discoloration from medication rheumatoid, Plaquenil side effect hyperpigmentation Does hydroxychloroquine get you high If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. While these medications contain the same active ingredient, the preparation of generic hydroxychloroquine can sometimes cause stomach irritation that usually does not occur with the brand name Plaquenil. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil & skin discoloration. Support Forums Lupus New Topic Reply. Native American, but the Plaquenil does make me extremely photosensitive. Of course it lightens some in the Winter months. Somehow I have managed to just live with it. Got tired of trying to hide it. Just take it in stride and go on. Melasma is reported only by a few people who take Plaquenil. We study 48,911 people who have side effects while taking Plaquenil from Food and Drug Administration FDA. Among them, 1 has Melasma. Find out below who they are, when they have Melasma and more. On eHealthMe, you can evaluate side effects and drug interactions from 15 million FDA. Oral tranexamic acid may cause side effects like nausea, diarrhea, and stomach issues. In rare cases, it can lead to anaphylaxis or vision problems. Melasma Home Remedies.