When lupus and constipation coincide, patients’ overall well-being is significantly affected. Chronic constipation can result in abdominal swelling, pain, and, in some cases, vomiting. Plaquenil and pepcid Pharmacokinetics of chloroquine Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Constipation is a very common digestive problem, and can have many different causes. Studies show that constipation can often exacerbate symptoms of bloating 23, 24. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Lupus constipation can be caused by a variety of factors. Given that lupus patients already have to deal with pain, fatigue, cognitive dysfunction and other distressing conditions, constipation makes their daily experience much more unpleasant. Plaquenil constipation Constipation and Sjogren's Syndrome - HealthBoards, Proven Ways to Reduce or Eliminate Bloating Chloroquine 200 mgCan aspirin interact badly with plaquenil RELISTOR ® methylnaltrexone bromide is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids. RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting chronic pain that is not caused by active cancer. RELISTOR Home Page. Hydroxychloroquine Plaquenil. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil usually has the opposite effect initially ! It's best to use dietary changes rather than a laxative, although I don't know exactly what it is you are taking. Drink plenty, more roughage/fibre prune juice or prunes all the usual stuff, cut out white flour products. I notice at once if I don't have my daily salad with dressing and fruit. The mechanism of action is thought to be anti-inflammatory, but Plaquenil also seems to reduce sensitivity to sunlight. It has also been noted recently that smoking reduces the effectiveness of Plaquenil in treating lupus, thus, smoking cessation should be instituted in all patients taking Plaquenil. More About Autoimmune diseases DERMATOMYOSITIS When lupus and constipation coincide, patients’ overall well-being is significantly affected. Chronic constipation can result in abdominal swelling, pain, and, in some cases, vomiting. Given that lupus patients already have to deal with pain, fatigue, cognitive dysfunction and other distressing conditions.