Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. How much chloroquine should i take for malaria New guidelines for plaquenil screening Small amounts of hydroxychloroquine can be found in breastmilk, but international experts indicate this medication is acceptable while breastfeeding. MECHANISM OF ACTION. Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. Hydroxychloroquine, an alkylated 4-aminoquinoline, is a hydroxylated form of chloroquine and has a biological mechanism of action similar to chloroquine’s. Hydroxychloroquine was originally developed as a safer alternative to chloroquine for the treatment of malaria and was later found to have antirheumatic and anti-inflammatory uses. Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine in rheumatoid arthritis mechanism of action REFERENCES - UpToDate, Hydroxychloroquine Information for Providers AIDSinfo Plaquenil and heart ratePlaquenil long qt Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. Hydroxychloroquine decreases Th17-related cytokines in.. Mechanisms of action of hydroxychloroquine and chloroquine.. Hydroxychloroquine Flashcards and Study Sets Quizlet. Hydroxychloroquine is an antimalarial drug. It treats malaria by killing the parasites that cause the disease. It isn’t fully understood how this drug works to treat lupus erythematosus or. In RA, hydroxychloroquine is designed to interfere with the interaction between T helper cells and antigen-presenting macrophages that cause joint inflammation and decrease the production of pro. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.