I remember the crushing fatigue and hope that I never have to feel that way again. I was on Plaquenil for over a year with my Limited Systemic Sclerosis and didn't notice any effect, scleroderma still progressing. :( Next week I am going to consult with my scleroderma doc what next. It's generally prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. I remained on that dosage for the first five years. You have to have you eyes checked on a very regular basis as it can cause visual changes and difficulty. Plaquenil sjogrens syndrome What else can i take if i cant take plaquenil Plaquenil retinal toxicity dose Usually you will start on a full dose of 200–400 mg daily, and later your doctor may reduce this. When your condition is very well controlled you may be advised to take hydroxychloroquine only 2–3 times per week. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares. The recommended adult dose for rheumatoid arthritis is 400-600 mg daily for 4-12 weeks followed by 200-400 mg daily. Systemic lupus erythematosus is treated with 400 mg once or twice daily for several weeks then 200-400 mg daily. Hydroxychloroquine should be taken with food or milk in order to reduce stomach upset. But it had an almost immediate effect for me with respect to fatigue, which I attribute to it's effect on vitamin D regulation (or dysregulation in my case). There have been times when I've stopped taking it over the years and have noticed no change in my fatigue or pain levels. The swelling/tendonitis in my fingers & toes stopped progressing after about 3 months, but 9 months later, they are still somewhat stiff and swollen, so it's difficult to know what would have happened without it. After that I was dropped to 200 mg two times a day. It's been a long time since I began taking it, but I don't remember any increase in energy. 200 mg of plaquenil how long to work RA and Hydroxychloroquine How Effective is it for Rheumatoid., How is plaquenil hydroxychloroquine used to treat lupus? Chloroquine-proguanil malaria prophylaxis Initial dose 400 mg 310 mg base orally once or twice a day for several weeks or months, depending on patient response Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Each dose should be taken with a meal or a glass of milk. Hydroxychloroquine Uses, Dosage & Side Effects -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. How long did Plaquenil/Hydroxychloroquine take.. Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. To 5’ 6 1/2” - up to 300 mg Plaquenil daily; 5’ or shorter - up to 200 mg Plaquenil daily; Women with lupus who are AT OR BELOW their ideal body weight should go by these dosing rules 135 lbs. or more, any height - up to 400 mg Plaquenil daily; 102 lbs. to 134 lbs. - up to 300 mg Plaquenil daily Mark a calendar to help you remember. This drug is usually started 2 weeks before entering the area with malaria. Take it once weekly while in the area, and continue taking it for 4 to 8 weeks after leaving the area or as directed by your doctor. To treat malaria, follow your doctor's instructions.