I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Chloroquine 250 mg side effects How quickly does damage from plaquenil What are plaquenil tablets used for Plaquenil and knee replacement They wanted me to go on steroids, but I have a really bad reaction with them, so now I don't know if there is anything I can be given to control my MCTD. Does anyone know if there is any other treatments or meds that have worked for you if you can't take Plaquenil or steroids? I take both prednisone and plaquenil. I heard someone once say that prednisone is the drug one loves to hate. It really does wonders to control inflammation, but has nasty side effects when given in large doses and/or used for a long period of time. My first experience with prednisone was horrific I was on 60mg per day, then on to 50, then 40. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Should you take plaquenil with steroids Rheumatoid Arthritis Treatment Options Johns Hopkins., Prednisone/Plaquenil question - Plaquenil malaria dosageG6pd and hydroxychloroquineHydroxychloroquine itpPlaquenil help arthritisHydroxychloroquine in diabetes ppt Medical treatment for lupus has made great strides within the last 50 years. This article will help you understand lupus treatments, lupus medications and side effects, and important lifestyle. Lupus Medications and Treatments. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Nov 11, 2019 Additionally, high-dosage or prolonged use of prednisone may reduce the immune response to certain vaccines and make them less effective. If you have been heavily treated with prednisone, you should wait for at least three months after stopping before getting a live vaccine. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Compare Plaquenil vs. Prednisone, which is better for uses like Lupus, RA and Sjogren's Syndrome. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Plaquenil 3.7/5 over Prednisone 3.2/5 in overall satisfaction.