There’s no cure for arthritis, which is unfortunate, but feeling better is definitely possible. The progression of RA may be diminished in severity and duration by the combination of medicines and therapy that work best as determined by you and your physician. Chloroquine phosphate effects on fish Lamictal and plaquenil Rheumatoid arthritis treatment includes medications that slow the progression of joint damage from rheumatoid. Hydroxychloroquine and. Methotrexate is the most commonly used DMARD. This is. The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients Lisa Schapink. The long-term impact of early treatment of rheumatoid arthritis on radiographic progression a population-based cohort study. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Being able to stop joint damage can lessen pain and mean a better quality of life. You can also put off joint damage, and in some cases, you can do more than just slow it down. Treatment rheumatoid arthritis with methotrexate and hydroxychloroquine Treatment of rheumatoid arthritis with methotrexate alone., Effects of methotrexate and hydroxychloroquine combination. Can plaquenil help osteoarthritisPlaquenil rash picturesToxicity of hydroxychloroquinePlaquenil dosage for osteoarthritisCan a blood test show if im taking plaquenil Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Hydroxychloroquine Side-effects, uses, time to work. Treatment of Rheumatoid Arthritis with Methotrexate Alone.. Hydroxychloroquine Plaquenil. Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 Given at a low dose, methotrexate is effective in controlling the swelling, pain, and stiffness that result from inflammation. In a significant percentage of patients, it also seems to slow the progression of rheumatoid arthritis and prevent damage to joints and related structures. 2,3. This medication comes in both pill and injectable forms. Methotrexate is the gold standard and is often prescribed to someone with rheumatoid arthritis that has active disease," Dr. Kaplan says. “And earlier treatment is best — once joint damage.