Plaquenil radiation therapy

Discussion in 'Chloroquine Drug' started by 3TOH, 05-Mar-2020.

  1. thehe8x_162 Well-Known Member

    Plaquenil radiation therapy


    Listing a study does not mean it has been evaluated by the U. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

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    Radiation therapy uses high-energy x-rays to kill tumor cells. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and to see how well they. Commencement of protocol therapy began as soon as medically appropriate, but, no later than 3 mo after craniotomy. All subjects received conventional external beam RT as utilized by the Radiation Therapy Oncology Group. This consisted of 60 Gy in 30 fractions delivered with megavoltage machines. Hydroxychloroquine in Treating Patients With Solid Tumors Undergoing Radiation Therapy for Bone Metastases. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government.

    Cohorts of 3-6 patients receive escalating doses of hydroxychloroquine until the maximum tolerated dose (MTD) is determined. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. cohorts of three pts: dose levels: 200, 400, 800mg. Other: pharmacological study (PK) pts continue on treatment until tumor progression. PKs - correlatives will be collected in Phase 1 Radiation (RT)Phse 2: daily hydroxychloroquine (HCQ) (MTD 600mg) on 1st day of RT and concomitant temozolomide for 6wks during RT. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. Other: pharmacological study (PK) Pts will continue on treatment until tumor progression. PURPOSE: This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and to see how well they work in treating patients with newly diagnosed glioblastoma multiforme. Complete 10 week cycle -Initiation Phase Maintenance cycles 1-6 HCQ daily TMZ D 1-5 150-200mg/m2 every 28 days. cohorts of three pts: dose levels: 200, 400, 800mg. Other: pharmacological study (PK) pts continue on treatment until tumor progression.

    Plaquenil radiation therapy

    Sarcoidosis - Diagnosis and treatment - Mayo Clinic, A phase I/II trial of. - PubMed Central PMC

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  4. This phase I / II trial studies the side effects and best dose of hydroxychloroquine and how well CPI-613 and hydroxychloroquine work in treating patients with high risk myelodysplastic syndrome that has come back after hypomethylating therapy. CPI-613 is thought to kill cancer cells by turning off their mitochondria.

    • Clinical Trials Using Hydroxychloroquine - National Cancer..
    • Hydroxychloroquine in Treating Patients With Solid Tumors..
    • Plaquenil.

    Iatrogenic immunosuppression, including radiation therapy; Multiple myeloma; CDC recommends you Give 1 dose of PCV13 and 2 doses of PPSV23. Administer PCV13 first, then give the first PPSV23 dose at least 8 weeks later. Give the second dose of PPSV23 at least 5 years after the first dose of PPSV23. I was told from the start by my rheumatologist I would have to have eye exams including visual field exams every six months due to the plaquenil therapy. My first two exams did include these tests. But my next six month appointment is coming up, and they told me I didn't need the visual field test this time so the appointment would be shorter. Free, official coding info for 2020 ICD-10-CM Z79.899 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.

     
  5. PS-RADIO-PS XenForo Moderator

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil Uses, Dosage & Side Effects - Plaquenil Hydroxychloroquine - Side Effects, Dosage. Will you have Sleep disorder with Plaquenil - eHealthMe
     
  6. md1 Moderator

    Hydroxychloroquine effectiveness in reducing symptoms of hand. Mar 02, 2013 Osteoarthritis OA is the most common type of arthritis, causing significant joint pain and disability. It is already a major cause of healthcare expenditure and its incidence will further increase with the ageing population. Current treatments for OA have major limitations and new analgesic treatments are needed.

    Plaquenil oral Reviews and User Ratings Effectiveness.
     
  7. Gil Galperin Guest

    Chloroquine Retinopathy - an overview ScienceDirect Topics Ocular complications of rheumatological therapies may relate to 1 direct drug-specific toxic effects, such as chloroquine retinopathy, 2 indirect drug-specific side-effects, such as corticosteroid-induced ocular hypertension resulting in secondary glaucoma, and 3 drug non-specific complications relating to immunosuppression, such as opportunistic infections.

    Ophthalmic Toxicities of Systemic Drug Therapy