Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil sulfa drug How does plaquenil make you feel Patients with new-onset rheumatoid arthritis had increased risk for ischemic and nonischemic heart failure Annals of Internal Medicine; 167 2 JC8 Review In rheumatoid arthritis, TNF-α inhibitors do not differ from placebo or DMARDs for all-cause mortality Stance was of some value, while toxic effects were seldom serious, but were relatively frequent with doses in excess of 250 mg. daily of chloroquine diphosphate or its equivalent. Bagnall 1957 reported that 71 per cent. ofa series of 108 patients with rheumatoid arthritis experienced remission or major improvement of symptoms during long-term treatment. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Common side effects include vomiting, headache, changes in vision and muscle weakness. Severe side effects may include allergic reactions. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine rheumatoid arthritis side effects Hydroxychloroquine Oral Route Side Effects - Mayo Clinic, CHLOROQUINE DIPHOSPHATE IN RHEUMATOID ARTHRITIS* Hydroxychloroquine eye floater Possible side effects of methotrexate include nausea, vomiting, and abnormal liver function. Some patients develop mouth sores, rash, or diarrhea. Tell your doctor if you develop shortness of breath or chronic cough. Additionally, some patients may experience hair loss. Rheumatoid Arthritis Treatment Side Effects. Hydroxychloroquine - Wikipedia. Chloroquine - Wikipedia. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. What Are Side Effects of Plaquenil? These side effects were seen most often in patients receiving large doses for treatment of lupus or rheumatoid arthritis; however, such reactions have been noted in patients taking therapeutic doses for short periods. Symptoms often resolved over time with a reduction of the dose or discontinuation of chloroquine.