As a result, the body produces antibodies that inflict cell damage, most commonly targeting joints, skin, kidneys and the nervous system. I recently started taking it in September and it seems like after about 5-10 minutes of taking it, I feel super tired and sleepy. Maybe try taking it with food and see if that helps. if your symptoms persist, you may need a change of dose. Join the group and find support for coping with lupus. I have read about the side effects and I do get the stomache discomfort but is the tiredness normal? but you may want to make sure your not taking too much. hugs I have been taking Plaquenil for quite a few years now, I don't think it's the Plaquenil making you tired...good ol' Lupus. I take 400mg a day and now 2 x Cyclosporin...to mention all the other stuff (I swear when I walk you can hear the rattle! Hi Phoebe, I have been on plaquenil for many years and have not experienced a sudden onset of fatigue after taking it. As Melissa stated plaquenil typically comes in 200mg tablets and 800 mg really seems like an aweful huge dose. Did your doctor tell you to take 2 tabs twice daily or you base on the label on your med bottle. Is there withdrawal from plaquenil Hydroxychloroquine and methotrexate We are on the verge of a global pandemic and this particularly unknown vaccine will arrive too late even if successful in the clinic and won't stop the spread of the SARS-CoV2 virus. Even worse. I have a lot of symptoms from Plaquenil, but for me I only notice a slight change in how it affects me. I went off of it for two months, and my Lupus got way worse. When I went back on it helped, but it doesn’t do as much as I would like it too. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. I've also tried to take 1 pill every couple of hours and that still doesn't prevent the fatigue feeling.... I usually take one in the morning and one at night. So far, I don't see any difference, but I guess it takes time. You might want to double check with your rheumy or prescribing doctor to inquire about your current dose and advise of your symptoms. I don't think there is a 100 mg tab, unless it is specially compounded. I have to take two pills in the am and two pills i the pm...sometimes I almost want to just skip the dose in the morning because it makes me feel worse than if I don't take anything. If so, I have never heard of anyone being on 800mg of plaquenil. You can look up the therapeutic doses online and it will tell you the highest dose you can take. Maybe that is why you are so tired after taking them. Taking it with food stops you feeling sick, and yes it takes a long time to kick in... While those of us with lupus never truly find anything to relieve fatigue, plaquenil is suppose to help with fatigue rather than create more from what I understand. The most I have ever taken is 400mg, I am currently on 300mg. I think there is probably some error or misunderstanding or miscommunication going on. Does plaquenil make a virus worse Does Taking Ibuprofen Make Coronavirus Worse? Experts Weigh., Does Plaquenil actually work for you? autoimmunity Plaquenil toxicity autofluorescencePancreatitis and plaquenilRetinal toxicity from plaquenil As it happens, many drugs can cause a lichenoid reaction that results in lichen sclerosus, including plaquenil, beta blockers, and even NSAIDs. However, about 9 out of 10 times, plaquenil is effective in *treating* lichen planus, so it's sort of a double-edged sword, with the odds far in favor of plaquenil helping more than hurting. Plaquenil Lichen Planus - Sclero Forums MAIN - Sclero Forums. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Did your doctor tell you that Plaquenil will help you with hair loss? My doctor said that it may not make it grow back to where it used to be but may stop further loss. So far, it's been a month since I have been taking it but I don't see any improvement. I think the hair shedding is same ot worse. Is your hair re-growing at all? Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. In an effort to do that, I changed my diet about a month ago. I've been eating a LOT of gluten, in the form of grain foods like cereal bars and granola. In the last month my joint pain has been even worse than usual, the nausea has been more constant and I've been feeling drained and weak.