Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine photosensitivity Hydroxychloroquine method of action Plaquenil aao 2016 Does plaquenil reduce rheumatoid arthritis Most patients do not experience many symptoms of retinal toxicity until it has progressed too far. Late stages include loss of visual acuity, peripheral vision and night vision. Patients who have been on Plaquenil longer than 5 years, are on a daily dose greater than 5mg/kg real body weight, have kidney problems or use the drug Tamoxifen may be at a higher risk for developing toxicity. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil retinal toxicity night vision Hydroxychloroquine-Induced Retinal Toxicity - American., Plaquenil Toxicity Screening Macula and Retina Institute c. Plaquenil aptt testPlaquenil pillPlaquenil retinalWeiggt gain tryibg to get off plaquenilRheumatoid arthritis methotrexate therapy hydroxychloroquine monotherapy Blurred vision, light sensitivity, seeing halos around lights, pale skin, easy bruising or; bleeding, confusion, unusual thoughts or behavior, or; seizures convulsions. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. The Risk of Retinal Toxicity with Plaquenil - Sjogren's. Multimodal Imaging in Plaquenil Toxicity. More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Plaquenil can produce pigment changes in the macula of the retina. The retina is the part of the back of the eye that you see with. The macula is the central part of the retina responsible for central fine vision. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. Retinal!toxicity.and!it!has!largely!replaced!chloroquine!as!a!treatment!ofinflammatory!disease. Unfortunately.the!retinal!damage!from!these!medications.