I took plaquenil for a while and it helped to reduce the duration/severity of the flairs, but I still had them. Both these drugs can take up to 3 months to begin to work. Plaqenil didn't stop my flare ups, but did ease some of the symptoms. It might also be worth checking what brand you have, as there are many posts on here about adverse reaction to a cheaper brand. Price check for plaquenil Chloroquine drug Is hydroxychloroquine safe from dr reddy's lab When plaquenil doesn t work Prednisone vs imuran. The plan is to begin Imuran WITH the plaquenil AND the prednisone, but hopefully this will allow for a lower daily dose of prednisone. As far as my suspicions go, I still believe that there is an additional neurological component to all of this. Lupus CAN affect the CNS, but is VERY serious. SIDE EFFECTS. The principal and potentially serious toxic effects of IMURAN are hematologic and risks of secondary infection and malignancy are also significant see WARNINGSfrequency and severity of adverse reactions depend on the dose and duration of IMURAN as well as on the patient's underlying disease or concomitant therapies. What it is Azathioprine or the brand name Imuran, is a drug that was originally developed to prevent organ rejection in people who had received a donor transplant. Currently, in addition to its anti-rejection properties, it is also being used more and more to treat autoimmune diseases like systemic lupus, dermatomyositis, vasculitis, rheumatoid arthritis and So it's worth taking some time to think about other possible causes. XBeen taking plaquenil for some 13 years now - seems to reduce the flairs but doesn't stop them. There are many possible triggers for a flare, & as lupus sufferers we are all different. Imuran plaquenil together Taking Imuran now-doctor adding Plaquenil. Is this semi., Side Effects of Imuran Azathioprine, Warnings, Uses Chloroquine vaccine Thanks for taking the time to reply I'm taking Plaquenil for 4 years the Imuran Azathioprine spwas added during the summer. I do feel better today I did come up with the malar rash which is a sure sign that a flair is on the way but as I said I feel better today and the rash is going down. Maybe the Imuran is working. I'm taking 400mg of plaquenil and 100mg of Imuran.. AZATHIOPRINE and Lupus - Kaleidoscope Fighting Lupus. Imuran Oral Uses, Side Effects, Interactions, Pictures.. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Does Tamoxifen CITRATE Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for.