One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Side effects hydroxychloroquine eyes Plaquenil prednisone and methotrexate FAF is an objective imaging test that uses the properties of the RPE to detect early toxicity. In early hydroxychloroquine toxicity, FAF often shows subtle parafoveal hyperautofluorescence, thought to be related to increased lipofuscin activity in the RPE. 4 In later stages of disease, hypoautofluorescence will be noted and is an indication of. Plaquenil Toxicity both Eyes - Partial Bull's Eye - Discontinued 6 Years ago Fundus Autofluorescence 1094 views 82-year-old woman was on Plaquenil from 1976 from 2005, 200 mg a day. It was discontinued because of abnormal visual fields 6 years ago. OD 20/32, OS 20/40 0 votes A multitude of tests are needed to detect the earliest possible signs of hydroxychloroquine toxicity, according to Andrew A. Moshfeghi, MD, MBA. “Widefield fundus autofluorescence and OCT. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity autofluorescence Fundus Autofluorescence - Innovative Eye Care, Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy. Plaquenil used for alopeciaHydroxychloroquine is it water pill Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Pattern of Retinopathy Although the locus of toxic damage. Recommendations on Screening for Chloroquine and.. Despite Plaquenil dosing recommendations, retinal toxicity.. New Screening Guidelines for Hydroxychloroquine Toxicity. The risk for Plaquenil toxicity increases after five years, and retinal changes take time to develop. So keep in mind that patients who have been switched to a newer medication could still demonstrate toxicity if they were once on Plaquenil. 1. Marmor MF, Kellner U, Lai TY, et al. American Academy of Ophthalmology. Fundus autofluorescence FAF is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Multiple commercially available imaging systems, including the fundus camera, the confocal scanning laser ophthalmoscope, and the ultra-widefield imaging device, are available to the. To detect chloroquine toxicity, the American Academy of Ophthalmology recommends performing fundus examinations, 10-2 automated visual fields, and at least one objective test multifocal electroretinography mfERG, fundus autofluorescence imaging, or spectraldomain optical coherence tomography SD-OCT. 1 By contrast, Amsler grid testing.