Chloroquine phosphate synthesis

Discussion in 'Northwest Pharmacy Canada' started by vap, 28-Feb-2020.

  1. svetka-m Moderator

    Chloroquine phosphate synthesis


    Visit Stack Exchange My intuition tells me that the nitrogen in the ring is more nucleophilic than the exocyclic amine. All this is not very promising and any attempt to optimize this reaction is fighting problems you would not have if you had decided for a more reasonable and well-established alternative in the first! A quick-and-dirty electrostatic potential calculation using B88LYP/6-31G(d) on the PM3 geometry shows a large electron density (blue and violet) on the ring nitrogen and lower density (yellow) on the exocyclic amine: Are there conditions that might work? That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures.

    Sjogren's i can't tolerate plaquenil Plaquenil 400 mg bugiardino Remove chloroquine phosphate

    Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. Note 250 mg of chloroquine phosphate is equivalent to 150 mg of chloroquine base. Chloroquine dose for the chemoprophylaxis of malaria 500 mg of chloroquine phosphate 300 mg base once a week on the same day each week. Initiate treatment one to two weeks before entering the endemic area and continue for four weeks after leaving it. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4. 7; chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup.

    It's a pretty untypical approach to chloroquine and you didn't tell how you would synthesize 7-chloro-3-aminoquinoline and the secondary chloride. There is a good chance that the planned reaction will furnish a quarternary ammonium salt as a side product: The reaction will not necessary stop at this point.

    Chloroquine phosphate synthesis

    Synthesis, Characterization and Complexation Behaviour of., Chloroquine Nivaquine, Resochin Healing Is Divine.

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  7. That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures.

    • Synthesis of chloroquine from 4-amino-7-chloroquinoline.
    • Chloroquine C18H26ClN3 - PubChem.
    • Design and Synthesis of Novel Chloroquine-based Antimalarials.

    Protein synthesis in situ by chloroquine in the culture, the. parasite eukaryotic initiation factor 2a- eIF-2a is phospho- rylated in the parasite lysate to a greater extent than that. observed in the control culture. Oct 04, 2019 A 16.67 mg chloroquine PHOSPHATE/mL oral suspension equivalent to 10 mg chloroquine BASE/mL may be made from tablets. Crush two 500 mg chloroquine PHOSPHATE tablets equivalent to 300 mg BASE/tablet in a mortar and reduce to a fine powder. Add a small amount of sterile water for irrigation. A New Synthesis of Chloroquine

     
  8. titan2000 New Member

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  9. novichok1 Guest

    CHLOROQUINE PHOSPHATE - Fishman Chemical, LLC USES Chloroquine Phosphate is a replacement for both copper sulfate and quinine and it is superior to copper sulfate and all quinine salts. Chloroquine is used as a bacteriacide, an algaecide and as an antimalarial. It is superior in the fight against ICH, slimness of the skin and flukes and can be used as both a treatment and a preventative.

    Hydroxychloroquine Sulfate Monograph for Professionals.