Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Hydroxychloroquine rash Plaquenil and muscle relaxor Allergy signs to hydroxychloroquine Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Sep 13, 2019 Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil reviews side effects PLAQUENIL Side Effects, Reviews by Patients page 3., Plaquenil Side Effects Common, Severe, Long Term - Sulfasalazine vs hydroxychloroquineWho chloroquine and flouroquinoloneTreatment chloroquine resistant malaria Side effects Severe self harm thoughts or urges, irritability, reactive depression, weight gain, uncontrollable crying, unrefreshing or poor sleep Evaluations from Patients who take Hydroxychloroquine.. Plaquenil Reviews Everyday Health. Hydroxychloroquine Side Effects Common, Severe, Long Term.. I'm not one to comment but I read so many reviews that sounded like either my ups or downs, so I want to encourage ppl to stick w/this med & try name brand though expensive if having bad side effects w/generic. It could explain why some ppl have such opposite experiences. I get Plaquenil from international pharm & it's much cheaper. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased. First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring.