Chloroquine in cancer therapy a double edged sword of autophagy

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    Chloroquine in cancer therapy a double edged sword of autophagy


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    Chloroquine side effects medscape Chloroquine hemolytic transfusion reaction What class of drug is hydroxychloroquine sulfate Synthesis of chloroquine from 4 7 dichloroquinoline

    Apr 13, 2009 Therefore, it is difficult to predict if inhibition of autophagy may sensitise resistant tumour cells to cytotoxic therapy. Fact is that autophagy plays a dual role in cancer. Our actual examinations suggest a basal enhanced level of autophagy in highly resistant cancer cells, which might promote growth and therapy resistance. Autophagy has been found to buffer metabolic stress and may help in cell survival; however, inhibiting autophagy under conditions of nutrient limitation can restore cell death to. The role of autophagy in tumorigenesis is complex and it could be a double-edged sword process, as autophagy defects promote cancer progression in association with various dangerous cellular processes, while functional autophagy enables cancer cell survival under stress and likely contributes to the resistance of treatment.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Frontiers Re-purposing Chloroquine for Glioblastoma., Autophagy-A double-edged sword in oncology Request PDF

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  5. Chloroquine reduces autophagy at a relatively late stage.7,11,21,22 Autophagy can be induced by several conditions, including anticancer agents Table I, and is regulated by a number of protein kinases, the best characterised being the mammalian target of rapamycin mTOR.8 Besides, there are several other mTOR-

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    Negative effects of autophagy; Cancer. the lysosomotropic agent chloroquine induces a myopathy in cultured cells and rats similar to that of a human disorder termed distal myopathy with rimmed vacuoles, as well as inclusion body myositis. A Double-Edged Sword. By Takahiro Shintani, Daniel J. Klionsky. Science 990-995. Sep 01, 2009 The emerging role of autophagy in cancer is one of a double-edged sword Figure 1B. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation and probably some forms of therapy. Cesses of autophagy is a more preferable approach in cancer therapy, however, and is now under investigation 28. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemo-therapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis,

     
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    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. PLAQUENIL Side Effects, Reviews by Patients - Plaquenil and Fibromyalgia - Plaquenil Drug and Medication User Reviews on RxList
     
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  8. idler Moderator

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia.

    Hydroxychloroquine-Induced Pigmentation in Patients With.