Chloroquine and cancer stem cells

Discussion in 'Plaquenil' started by Ailitir, 14-Mar-2020.

  1. narvatkina New Member

    Chloroquine and cancer stem cells


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    Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling Article PDF Available in Molecular Cancer Therapeutics 137 April 2014 with 251 Reads Chloroquine CQ eliminates cancer stem cell CSC subpopulations in TNBC. CQ causes structural mitochondrial damage, resulting in oxidative DNA breaks. CQ hinders the homologous recombination necessary for DNA break repair in CSCs. Moreover, organs in which autophagy also plays a homeostatic role, such as the neurons, liver, hematopoietic stem cells, and heart, may be sensitive to the combined use of chloroquine and anticancer drugs. Here, we summarize the functions of autophagy in cancer and kidney injury, especially focusing on the use of chloroquine to treat cancer.

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    Chloroquine and cancer stem cells

    Chloroquine eliminates cancer stem cells through., The autophagy inhibitor chloroquine targets cancer stem cells in triple.

  2. 3-hydroxychloroquine
  3. Triple negative breast cancer TNBC is known to contain a high percentage of CD44 +/CD24 −/low cancer stem cells CSC, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an anti-malarial drug, is a lysotropic reagent which inhibits autophagy.

    • Chloroquine eliminates cancer stem cells through deregulation..
    • Chloroquine in Cancer Therapy A Double-Edged Sword of..
    • The autophagy inhibitor chloroquine targets cancer stem..

    Triple negative breast cancer TNBC is known to contain a high percentage of CD44+ /CD24-/low cancer stem cells CSCs, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an antimalarial drug, is a lysotropic reagent which inhibits autophagy. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Balic A1, Sørensen MD2, Trabulo SM3, Sainz B Jr1, Cioffi M1, Vieira CR1, Miranda-Lorenzo I1, Hidalgo M4, Kleeff J5, Erkan M5, Heeschen C6. Pancreatic cancer cell line PaTu II 12, the effects of chloroquine on tumor growth were later. confirmed in mouse models of PDAC and attributed to the inhibition of autophagy 13, which is. responsible for recycling bioenergetic components to ensure cell survival in nutrient-deprived. times or locations 13.

     
  4. anddro User

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  5. vvmartin User

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine Indications, Side Effects, Warnings - Plaquenil Oral Uses, Side Effects, Interactions. Aralen Chloroquine Uses, Dosage, Side Effects.
     
  6. Xena Guest

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    Hydroxychloroquine Oral Tablet 200Mg Drug Medication Dosage.