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    Verschiedenen Studien zufolge ist das Leaky-Gut-Syndrome entscheidend an der Pathogenese von Autoimmunerkrankungen (Hashimoto-Thyreoditis, Autoimmunhepatitis, Zöliakie, chronisch-entzündliche Darmerkrankungen, Multiple Sklerose, Diabetes mellitus, Rheumatoide Arthritis und Lupus erythematodes) beteiligt. Die Inflammationsprozesse der Darmmukosa können zu einer Umprogrammierung des Immunsystems führen und legen bei genetischer Prädisposition so das Fundament für die Entstehung einer Autoimmunkrankheit. Über die Nahrungsaufnahme kommt der humane Organismus täglich mit körperfremden Stoffen in Kontakt. Die intestinale Permeabilität entscheidet, welche Stoffe aufgenommen und welche ausgeschieden werden. Die Darmbarriere wird durch die Darmepithelzellen, die über Tight Junctions miteinander verbunden sind, aufrechterhalten. Der Transport der über die Nahrung aufgenommenen Stoffe erfolgt über einen parazellulären oder einen transzellulären Transport. Eine Schädigung der Darmmukosa kann in einem Leaky-Gut-Syndrom resultieren. Crohn, Colitits ulcerosa), bestimmte Medikamente (Ibuprofen, Aspirin, Chemotherapeutika), Alkoholkonsum, Nahrungsmittelintoleranzen (Laktose, Gluten), Bakterien, Viren und psychischer Stress können die Entstehung eines Leaky-Gut-Syndroms triggern. , are many links to Vitamin Cs therapeutic-range pharmacokinetics and related biochemical global knowledge on ascorbate, which can be used to moderate chronic and acute inflammation and allergic flares and which in therapeutic level dosages has been found to act as an antimicrobial and antiviral antibiotic. of metal toxicity by Practitioners and Medical Regulators turns the combination of risky, commonly prescribed diagnostics and therapies into a pernicious synergistic nightmare, amplified by genetic and hormonal factors. Lead, Mercury, Aluminum, Gadolinium tissue persistence in combination magnify the single-metal concentration toxic effects., perhaps thousands of unknown vital biochemical pathways. Nutritional, essential biochemical factors, C & B vitamins and their functional biochemistry, are significantly ignored in proposed new opioid recovery The book is thought-provoking and is a highly recommended account of some invalid denials of competent research findings by health administration research gatekeepers. Absence of Evidence is not Evidence of Absence; it may be proof of incompetence and suppression of excellence. Xylitol can reduce plaque formation in our endothelias microbiomes. There is evidence that high-carb and certain carbs eaten can selectively modulate our biochemistry, of evidence is worse than ignorance of evidence; Absence of evidence is not evidence of absence. Evidence-based-science with selection-bias is not science; it is false political rhetoric; it is everywhere.

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  5. OPEN. ORIGINAL ARTICLE. Metformin ameliorates experimental-obesity- associated autoimmune arthritis by inducing FGF21 expression.

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