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    In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover). VIAGRA was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years. VIAGRA demonstrated statistically significant improvement compared to placebo in all 21 studies. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. The effectiveness of VIAGRA was evaluated in most studies using several assessment instruments. The primary measure in the principal studies was a sexual function questionnaire (the International Index of Erectile Function - IIEF) administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment. diflucan sale The little blue pill may not have ever been if not for one dutiful nurse. Viagra, Pfizer’s blockbuster erectile dysfunction drug hit the market in 1998. In 20 years, it’s become ubiquitous: 62 million men all over the world have bought the drug, according to a Pfizer spokesperson. The US military shells out $41.6 million per year for it, and from 2012 onward, the US, Mexico, and Canada spent about $1.4 billion on it annually (although those numbers are projected to fall in the coming years when Pfizer’s patent on the drug expires in 2020). Despite the drug’s popularity today, the researchers who discovered it weren’t even looking for it. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart’s blood vessels by blocking a particular protein called PDE-5.

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    Dr Wheate in the past has received funding from the ACT Cancer Council, Tenovus Scotland, Medical Research Scotland, Scottish Crucible and the Scottish Universities Life Sciences Alliance for research into platinum drugs. Dr Wheate is a named inventor on two international patents dealing with the drug delivery of anticancer drugs. Viagra is one brand name of a drug that is used to treat erectile dysfunction (impotence): the inability to get, and maintain, an erection. It is also used in the treatment of high blood pressure specific to the heart and the arteries that feed the lungs. The generic name of the drug is sildenafil (pronounced sill-den-a-fill). Like many great scientific discoveries, the benefits of Viagra in treating erectile dysfunction were discovered by accident. The pharmaceutical company Pfizer initially developed the drug in 1989 as a treatment for high blood pressure and angina. The "little blue pill" could one day have a surprising use: as a cancer prevention drug. Early research in mice suggests that small doses of sildenafil, the ingredient in Viagra responsible for the pill's effects, may prevent colorectal cancer. When the researchers gave the drug to mice that were prone to developing colorectal cancer, the drug was linked to a 50 percent reduction in the number of precancerous polyps that formed in the animals' intestines, compared with mice that weren't given the drug. Still, much more work is needed before researchers will know if Viagra has the same effect in people, the study researchers said. [Viagra Goes Generic: 5 Interesting Facts About the ' Little Blue Pill'] Next steps include testing Viagra in a clinical trial of patients who have a high risk of colorectal cancer, such as people with a family history of the disease, study co-author Darren Browning, a cancer researcher at Augusta University Georgia Cancer Center, said in a statementearlier this month. The mice used in the study had a mutation in a gene called "adenomatous polyposis coli" or APC. This mutation is also found in humans and results in the formation of hundreds of polyps starting in the teenage years, and these growths lead to colorectal cancer, Browning said.

    Viagra research

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